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Subcorneal pustular dermatosis

29 September 2015, by WALLACH D. & VIGNON-PENNAMEN M-D.

Subcorneal pustular dermatosis was first described in 1956 by Ian B. Sneddon and Darrell S. Wilkinson [4]. Initially, subcorneal pustular dermatosis was isolated from other bullous dermatoses, including dermatitis herpetiformis; the condition is likely to correspond to older descriptions of pustular forms of “Duhring-Brocq disease”. During the 1980s, the focus was on the distinction, disputed by some, between subcorneal pustular dermatosis and some forms of pustular psoriasis. At present, subcorneal pustular dermatosis is recognised to exist as an autonomous entity. Recent publications have added two important ideas:

— Subcorneal pustular dermatosis belongs to the group of neutrophilic dermatoses.

— IgA-mediated immunological abnormalities are common due to the involvement of IgA antiepidermal transgluaminase antibodies that defines intraepidermal IgA pustulosis (IgA pemphigus) and an association with IgA monoclonal gammopathies.

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